Genomic-Based Tools to Support the Control of Urogenital Schistosomiasis and Hepatic Opisthorchiasis

Molecular evidence for distinct modes of nutrient acquisition between visceral and neurotropic schistosomes of birds

R Leontovyč, ND Young, PK Korhonen, RS Hall, J Bulantová, V Jeřábková, M Kašný, RB Gasser, P Horák

2019-12-01

Trichobilharzia species are parasitic flatworms (called schistosomes or flukes) that cause important diseases in birds and humans,..

Comparative genome analysis indicates high evolutionary potential of pathogenicity genes in Colletotrichum tanaceti

RV Lelwala, PK Korhonen, ND Young, JB Scott, PK Ades, RB Gasser, PWJ Taylor

2019-05-01

Colletotrichum tanaceti is an emerging foliar fungal pathogen of commercially grown pyrethrum (Tanacetum cinerariifolium). Despite..

Programmed knockout mutation of liver fluke granulin attenuates virulence of infection-induced hepatobiliary morbidity

Patpicha Arunsan, Wannaporn Ittiprasert, Michael J Smout, Christina J Cochran, Victoria H Mann, Sujittra Chaiyadet, Shannon E Karinshak, Banchob Sripa, Neil David Young, Javier Sotillo, Alex Loukas, Paul J Brindley, Thewarach Laha

2019-01-15

Infection with the food-borne liver fluke Opisthorchis viverrini is the principal risk factor (IARC Working Group on the Evaluatio..

Deguelin exerts potent nematocidal activity via the mitochondrial respiratory chain

S Preston, PK Korhonen, L Mouchiroud, M Cornaglia, SL McGee, ND Young, RA Davis, S Crawford, C Nowell, BRE Ansell, GM Fisher, KT Andrews, BCH Chang, MAM Gijs, PW Sternberg, J Auwerx, J Baell, A Hofmann, A Jabbar, RB Gasser

2017-10-01

As a result of limited classes of anthelmintics and an over-reliance on chemical control, there is a great need to discover new co..

Genomics of worms, with an emphasis on Opisthorchis viverrini — opportunities for fundamental discovery and biomedical outcomes

RB Gasser, P Tan, BT Teh, S Wongkham, ND Young

2017-08-01

Neglected tropical diseases cause substantial morbidity and mortality in animals and people globally. Opisthorchiasis is one such ..

Oestrous cycle-dependent equine uterine immune response to induced infectious endometritis

CD Marth, SM Firestone, LY Glenton, GF Browning, ND Young, N Krekeler

2016-11-08

© 2016 The Author(s). Infectious endometritis is a major cause of reduced pregnancy rates in horses. The objectives of this study ..

Making sense of genomes of parasitic worms: Tackling bioinformatic challenges

PK Korhonen, ND Young, RB Gasser

2016-09-01

Billions of people and animals are infected with parasitic worms (helminths). Many of these worms cause diseases that have a major..

Comparative Transcriptomic Exploration Reveals Unique Molecular Adaptations of Neuropathogenic Trichobilharzia to Invade and Parasitize Its Avian Definitive Host

R Leontovyč, ND Young, PK Korhonen, RS Hall, P Tan, L Mikeš, M Kašný, P Horák, RB Gasser

2016-02-10

To date, most molecular investigations of schistosomatids have focused principally on blood flukes (schistosomes) of humans. Despi..

Whole transcriptome profiling of adult and infective stages of the trematode Opisthorchis felineus

MY Pomaznoy, MD Logacheva, ND Young, AA Penin, NI Ershov, AV Katokhin, VA Mordvinov

2016-02-01

Opisthorchis felineus, the trematode belonging to the family Opisthorchiidae, is a causative agent of the infection called opistho..

Pipeline for the identification and classification of ion channels in parasitic flatworms

B Nor, ND Young, PK Korhonen, RS Hall, P Tan, A Lonie, RB Gasser

2016-01-01

Background: Ion channels are well characterised in model organisms, principally because of the availability of functional genomic ..